Browsing by Author "Kagira, John M"
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Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys
Kagira, John M; Thuita, John K; Ngotho, Maina; Mdachi, Raymond; Mwangangi, David M; Ndung’u, Joseph M (African Journal of Health Sciences,, 2006)Haematological aberrations associated with human infective trypanosomes were investigated in the vervet monkey model of the Rhodesian sleeping sickness. Four monkeys were infected intravenously with 104 Trypanosoma brucei ... -
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis
Thuita, John K; Wang, Michael Z; Kagira, John M; Denton, Cathrine L; Paine, Mary F; Mdachi, Raymond E; Murilla, Grace A; Ching, Shelley; Boykin, David W; Tidwell, Richard R; Hall, James E; Brun, Reto (PLOS, 2012)Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ...