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Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of Human African Trypanosomiasis.
(PLOS, 2008)
We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei
rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis
(Elsevier, 2008)
The choice of drugs for the treatment of sleeping sickness is extremely limited. To redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, ...