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Development of a specimen-sparing multichannel bead assay to detect antiparasite IgG4 for the diagnosis of Schistosoma and Wuchereria infections on the coast of Kenya
(The American Society of Tropical Medicine and Hygiene, 2014)
To better delineate the impact of parasitic coinfection in coastal Kenya, we developed a novel specimen-sparing bead assay using multiplex flow immunoassay (MFI) technology to simultaneously measure serum or plasma ...
Birthweight in offspring of mothers with high prevalence of helminth and malaria infection in coastal Kenya
(The American Society of Tropical Medicine and Hygiene, 2013)
Results of studies on the associations of maternal helminth infection and malaria-helminth co-infection on birth outcomes have been mixed. A group of 696 pregnant women from the Kwale district in Kenya were recruited and ...
Effect of antenatal parasitic infections on anti-vaccine IgG levels in children: a prospective birth cohort study in Kenya
(Public Library of Science, 2015)
Parasitic infections are prevalent among pregnant women in sub-Saharan Africa. We investigated whether prenatal exposure to malaria and/or helminths affects the pattern of infant immune responses to standard vaccinations ...
Cord blood antiparasite interleukin 10 as a risk marker for compromised vaccine immunogenicity in early childhood
(The Journal of Infectious Diseases, 2018-01)
Antenatal exposure to parasites can affect infants’ subsequent responses to vaccination. The present study investigated
how maternal prenatal infections and newborns’ antiparasite cytokine profiles relate to immunoglobulin ...
In utero activation of fetal memory T cells alters host regulatory gene expression and affects HIV susceptibility
(Academic Press, 2012)
The HIV-1 CCR5 co-receptor is a member of the chemokine receptor family of G-protein coupled receptors;for which a number of small molecule antagonists, such as vicriviroc (VCV), have been developed to inhibit HIV-1 R5-tropic ...