Browsing School of Agriculture & Food Science by Author "Brun, Reto"

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    • Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys 

      Thuita, John K.; Wolf, Kristina K.; Murilla, Grace A.; Bridges, Arlene S.; Boykin, David W.; Mutuku, James N.; Liu, Qiang; Jones, Susan K.; Gem, Charles O.; Tidwell, Richard R.; Wang, Michael Z.; Paine, Mary F.; Brun, Reto (PLOS, 2014)
      Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central ...

    • Diamidines for human African trypanosomiasis 

      Paine, Mary F; Wang, Michael Zhuo; Generaux, Claudia N; Boykin, David W; Wilson, W David; Koning, Harry P De; Olson, Carol A; Pohlig, Gabriele; Burri, Christian; Brun, Reto; Murilla, Grace A; Thuita, John K; Barrett, Michael P; Tidwell, Richard R (Thomson Reuters, 2010)
      Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active ...

    • Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis 

      Thuita, John K; Wang, Michael Z; Kagira, John M; Denton, Cathrine L; Paine, Mary F; Mdachi, Raymond E; Murilla, Grace A; Ching, Shelley; Boykin, David W; Tidwell, Richard R; Hall, James E; Brun, Reto (PLOS, 2012)
      Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ...

    • Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypano 

      Thuita, John K; Wolf, Kristina K; Murilla, Grace A; Liu, Qiang; Mutuku, James N; Chen, Yao; Bridges, Arlene S; Mdachi, Raymond E; Ismail, Mohamed A; Ching, Shelley; Boykin, David W; Hall, James Edwin; Tidwell, Richard R; Paine, Mary F; Brun, Reto; Wang, Michael Zhuo (PLOS, 2013)
      There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs ...