Browsing School of Agriculture & Food Science by Author "Thuita, John K"

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    • Diamidines for human African trypanosomiasis 

      Paine, Mary F; Wang, Michael Zhuo; Generaux, Claudia N; Boykin, David W; Wilson, W David; Koning, Harry P De; Olson, Carol A; Pohlig, Gabriele; Burri, Christian; Brun, Reto; Murilla, Grace A; Thuita, John K; Barrett, Michael P; Tidwell, Richard R (Thomson Reuters, 2010)
      Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active ...

    • Differential Virulence and Tsetse Fly Transmissibility of Trypanosoma Congolense and Trypanosoma Brucei Strains 

      Gitonga, Purity K; Ndung'u, Kariuki; Murilla, Grace A; Thande, Paul C; Wamwiri, Florence N; Auma, Joanna E; Ngae, Geoffrey N; Kibugu, James K; Kurgat, Richard; Thuita, John K (AOSIS, 2017)
      African animal trypanosomiasis causes significant economic losses in sub-Saharan African countries because of livestock mortalities and reduced productivity. Trypanosomes, the causative agents, are transmitted by tsetse ...

    • Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys 

      Kagira, John M; Thuita, John K; Ngotho, Maina; Mdachi, Raymond; Mwangangi, David M; Ndung’u, Joseph M (African Journal of Health Sciences,, 2006)
      Haematological aberrations associated with human infective trypanosomes were investigated in the vervet monkey model of the Rhodesian sleeping sickness. Four monkeys were infected intravenously with 104 Trypanosoma brucei ...

    • Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis 

      Thuita, John K; Wang, Michael Z; Kagira, John M; Denton, Cathrine L; Paine, Mary F; Mdachi, Raymond E; Murilla, Grace A; Ching, Shelley; Boykin, David W; Tidwell, Richard R; Hall, James E; Brun, Reto (PLOS, 2012)
      Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ...

    • Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypano 

      Thuita, John K; Wolf, Kristina K; Murilla, Grace A; Liu, Qiang; Mutuku, James N; Chen, Yao; Bridges, Arlene S; Mdachi, Raymond E; Ismail, Mohamed A; Ching, Shelley; Boykin, David W; Hall, James Edwin; Tidwell, Richard R; Paine, Mary F; Brun, Reto; Wang, Michael Zhuo (PLOS, 2013)
      There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs ...