Browsing School of Agriculture & Food Science by Author "Thuita, John K."
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Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Thuita, John K.; Wolf, Kristina K.; Murilla, Grace A.; Bridges, Arlene S.; Boykin, David W.; Mutuku, James N.; Liu, Qiang; Jones, Susan K.; Gem, Charles O.; Tidwell, Richard R.; Wang, Michael Z.; Paine, Mary F.; Brun, Reto (PLOS, 2014)Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central ... -
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis
Thuita, John K.; Karanja, S.M.; Wenzler, T.; Mdachi, R.E.; Ngotho, J.M.; Tidwell, R.; Brun, R. (Elsevier, 2008)The choice of drugs for the treatment of sleeping sickness is extremely limited. To redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, ... -
Kenya Trypanosomiasis Research Institute Cryobank for Human and Animal Trypanosome Isolates to Support Research: Opportunities and Challenges
Grace, A. Murilla; Ndung’u, Kariuki; Thuita, John K.; Gitonga, Purity K.; Kahiga, Daniel T.; Auma, Joanna E.; Ouma, Johnson O.; Rutto, Jane J.; Ndung’u, Joseph M. (2014) -
Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of Human African Trypanosomiasis.
Thuita, John K.; Kagira, John M.; Mwangangi, David; Matovu, Enock; Turne, C. M. R.; Masiga, Daniel (PLOS, 2008)We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...