Browsing School of Agriculture & Food Science by Author "Thuita, John Kibuthu"
Now showing items 1-5 of 5
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Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense
Nyariki, James Nyabuga; Thuita, John Kibuthu; Nyambati, Grace Kemunto; Isaac, Alfred Orina (Journal of Coastal Life Medicine, 1997)Objective: To establish the modulatory effects of coenzyme Q10 on experimental trypanosome infections in mice and evaluate the risk of occurrence and severity of melarsoprol-induced post treatment reactive encephalopathy ... -
Comparative Pathogenicity of Trypanosoma brucei rhodesiense Strains in Swiss white Mice and mastomys natalensis Rats
Muchiri, Margaret Wanjiku; Ndung'u, Kariuki; Kibugu, James Karuku; Thuita, John Kibuthu; Gitonga, Purity Kaari; Ngae, Geoffrey Njuguna; Mdachi, Raymond Ellie; Kagira, John Maina (2015)Abstract We evaluated Mastomys natelensis rat as an animal model for Rhodesian sleeping sickness. Parasitaemia, clinical and pathological characteristics induced by T. b. rhodesiense isolates, KETRI 3439, 3622 and 3637 ... -
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model
Ndung’u, Kariuki; Murilla, Grace Adira; Thuita, John Kibuthu; Ngae, Geoffrey Njuguna; Auma, Joanna Eseri; Gitonga, Purity Kaari; Thungu, Daniel Kahiga; Kurgat, Richard Kiptum; Chemuliti, Judith Kusimba; Mdachi, Raymond Ellie (2020)We assessed the virulence and anti-trypanosomal drug sensitivity patterns of Trypanosoma brucei rhodesiense (Tbr) isolates in the Kenya Agricultural and Livestock Research Organization-Biotechnology Research Institute ... -
Infectra(®)-kit: a device for restraining mice and confining tsetse flies during trypanosome infection transmission experiments
Ndung'u, Kariuki; Kibugu, James Karuku; Gitonga, Purity Kaari; Thuita, John Kibuthu; Auma, Joanna Eseri; Gitonga, Samuel Kariuki; Ngae, Geoffrey Njuguna; Murilla, Grace Adira (Elsevier, 2013)Chemical (anaesthesia) and manual techniques are commonly used to restrain mice during vector-mediated parasite transmission experiments in the laboratory. Chemical restraint may interfere with natural fly vector-mouse ... -
Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)
Maina, Naomi; Ngotho, Joseph Maina; Were, Tom; Thuita, John Kibuthu; Mwangangi, David Mumo; Kagira, John Maina; Ndung'u, Joseph Mathu; Sternberg, Jeremy (2004)A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of ...