Browsing School of Agriculture & Food Science by Author "Wang, Michael Zhuo"

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    • Diamidines for human African trypanosomiasis 

      Paine, Mary F; Wang, Michael Zhuo; Generaux, Claudia N; Boykin, David W; Wilson, W David; Koning, Harry P De; Olson, Carol A; Pohlig, Gabriele; Burri, Christian; Brun, Reto; Murilla, Grace A; Thuita, John K; Barrett, Michael P; Tidwell, Richard R (Thomson Reuters, 2010)
      Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active ...

    • Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypano 

      Thuita, John K; Wolf, Kristina K; Murilla, Grace A; Liu, Qiang; Mutuku, James N; Chen, Yao; Bridges, Arlene S; Mdachi, Raymond E; Ismail, Mohamed A; Ching, Shelley; Boykin, David W; Hall, James Edwin; Tidwell, Richard R; Paine, Mary F; Brun, Reto; Wang, Michael Zhuo (PLOS, 2013)
      There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs ...