Browsing School of Agriculture & Food Science by Subject "Sleeping sickness"

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    • Diamidines for human African trypanosomiasis 

      Paine, Mary F; Wang, Michael Zhuo; Generaux, Claudia N; Boykin, David W; Wilson, W David; Koning, Harry P De; Olson, Carol A; Pohlig, Gabriele; Burri, Christian; Brun, Reto; Murilla, Grace A; Thuita, John K; Barrett, Michael P; Tidwell, Richard R (Thomson Reuters, 2010)
      Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active ...

    • Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis 

      Thuita, John K.; Karanja, S.M.; Wenzler, T.; Mdachi, R.E.; Ngotho, J.M.; Tidwell, R.; Brun, R. (Elsevier, 2008)
      The choice of drugs for the treatment of sleeping sickness is extremely limited. To redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, ...