Hygiene practices are essential for maintaining public health and preventing the spread of infectious diseases. Mass media has the potential to influence individuals’ hygiene behaviors and attitudes. By reaching a wide and diverse audience simultaneously, mass media can effectively disseminate targeted hygiene-related messages, leading to improved knowledge. However, the effectiveness of mass media is often inadequately assessed and evaluated. Poor hygiene practices have led to regular outbreaks of water borne diseases in Garba Tula Sub-County. Consequently, a cross-sectional study was conducted in Garba Tula Sub-County to achieve the following objectives; to assess the hygiene practices prevalent in Garba Tula, to assess mass media sources that promote good hygiene practices and to assess the relationship between mass media and hygiene practices in the area. The study employed a convergent design. Quantitative data was gathered by use of structured questionnaires from 191 household heads sampled using a simple random technique. Data was analyzed by use of SPSS (2022) and ANOVA, inferential statistics was done and presented in figures, graphs and tables. Key informant interviews were conducted and data gathered was analyzed thematically and findings were presented in narratives. The study established that 54 (40%) of the respondents practiced open defecation, 36 (26%) had a family latrine while 26 (19%) of the respondents shared latrines. Besides, 78 (57%) of the respondents washed their hands with water and soap after latrine use. However, 69 (51%) of the respondents indicated that lack of water hindered them from handwashing. The study also revealed that radio was the most accessible media source 109 (80%) and was used to promote hygiene practices. The study also noted there was a low relationship (p<0.001) between the households without media access and hygiene practices. The study concluded that inadequate awareness and cultural beliefs were the primary causes of poor hygiene practices in the study area. Mass media, particularly radio, played a significant role in raising awareness and educating the community about the importance of good hygiene practices. The study recommends the county government of Isiolo ensures the households have access to latrines and safety of water sources. Also, more information on importance of good hygiene practices should be available and accessible to the residents of Garba Tula sub-county.