| dc.contributor.author | Ombuya, Jared Nyangau | |
| dc.date.accessioned | 2024-04-30T11:56:36Z | |
| dc.date.available | 2024-04-30T11:56:36Z | |
| dc.date.issued | 2023 | |
| dc.identifier.citation | A Thesis submitted in partial fulfillment of the requirement for the conferment of Master`s Degree in Sanitation of Meru University of Science and Technology | en_US |
| dc.identifier.uri | http://repository.must.ac.ke/handle/123456789/1067 | |
| dc.description.abstract | The aim of this study was to evaluate antimicrobial susceptibility patterns of Escherichia coli and Salmonella spp. in Majengo slum that have emerged due to poor sanitation implementation. Multidrug resistance of E. coli and Salmonella has increased in the recent years and this has led to resistance of microorganisms to antimicrobials. The impact of antimicrobial resistance will be high mortality rates being recorded especially among young children in low income areas. Antimicrobial drug resistant is of great concern today since the rate of use and misuse has increased and organisms are changing the genetic make up to survive on the environment. Poor sanitation is one of the cause of this resistance in the globe currently. The main objective was evaluation of antimicrobial resistant strains of E. coli and Salmonella spp. Isolated from Sanitation Environments of Majengo Slum in Meru County, Kenya. The study employed standard microbiological procedure such as culturing on MacConkey agar, biochemical testing for the confirmation of the organisms’ presence using TBX agar and Indole test for E. coli and TSI test for Salmonella spp and Urea agar and microbial susceptibility profile on Muller Hinton agar using commonly used antibiotics for enteric bacteria. Statistical analysis revealed a significance in comparison between the two strata (P 0.00052). Highest resistance was shown to Cefoxitin 22(52.38%) while the least was Ciprofloxacin 4(9.52%). Ceftazidime showed highest sensitivity 28(66.67%) while Cefoxitin showed least sensitivity 13(30. 95%).Data was entered into Microsoft Excel 2010 and analyzed using SPSS version 26. Data was compared between each study strata and between each sample type using Kruskal-Wallis tests, and between the two drugs using the Wilcoxon Signed Rank tests. This study showed that E. coli isolated from Majengo is pathogenic and resistant to antibiotics. Detection of E.coli pose a great risk in the spread of resistant strains in human. However, further research should be carried to find out the resistant genes of organism in this study area. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Meru University of Science and Technology | en_US |
| dc.subject | Antimicrobial | en_US |
| dc.subject | Escherichia Coli and Salmonella SPP | en_US |
| dc.title | Evaluation of Antimicrobial susceptibility of Escherichia Coli and Salmonella Spp.isolated from contaminated areas of Majengo slum in Meru County, Kenya | en_US |
| dc.type | Thesis | en_US |
