School of Agriculture & Food Science: Recent submissions
Now showing items 61-80 of 248
-
Development of a rodent model for late stage rhodesian sleeping sickness
(National Research Center for Protozoan Diseases, 2007)A mouse model of Trypanosoma brucei rhodesiense that can be used in pathogenesis and drug studies for Human African Trypanosomosis (HAT) has so far not been developed. In an attempt to develop such a model, a study was ... -
Hematological changes in vervet monkeys (Chlorocebus aethiops) during eight months' adaptation to captivity
(American Journal of Primatology, 2007)This study investigated fluctuations in hematological values of 50 wild-caught vervet monkeys (African green monkeys, grivets, Chlorocebus aethiops) during habituation to captivity. The monkeys were categorized into four ... -
Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys
(African Journal of Health Sciences,, 2006)Haematological aberrations associated with human infective trypanosomes were investigated in the vervet monkey model of the Rhodesian sleeping sickness. Four monkeys were infected intravenously with 104 Trypanosoma brucei ... -
Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of Human African Trypanosomiasis.
(PLOS, 2008)We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ... -
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration
(American Society for Microbiology, 2009)10 to 30 days to facilitate treatment with parenterally administered medicines. The efficacy of a novel orally administered prodrug, 2,5-bis(4-amidinophenyl)-furan-bis-O-methlylamidoxime (pafuramidine, DB289), was tested ... -
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis
(Elsevier, 2008)The choice of drugs for the treatment of sleeping sickness is extremely limited. To redress this situation, the recently synthesised diamidine, 2,5-bis(4-amidinophenyl)-furan (DB75, furamidine) and its methamidoxime prodrug, ... -
Diamidines for human African trypanosomiasis
(Thomson Reuters, 2010)Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active ... -
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis
(PLOS, 2012)Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy (NECT) to WHO Model Lists of Essential Medicines against second ... -
Invasive Plant Species and Biomass Production in Savannas
(InTech: Biomass and Remote Sensing of Biomass, 2011)Savannas are the second largest biome accounting for c. 30% of terrestrial production. Tropical savannas are distributed largely in Africa, Australia and South America occurring between tropical ... -
A botanical inventory and diversity assessment of Mt. Marsabit forest, a sub-humid montane forest in the arid lands of northern Kenya
(African Journal of Ecology, 2007)A botanical inventory and diversity of trees, shrubs (‡5cm diameter at breast height [dbh]), herbs, climbers and lianas was assessed in plots (154) of 20 · 5 m in Mt. Marsabit forest, northern Kenya. We recorded 52 species ... -
Competition between cultivated rice (Oryza sativa) and wild rice (Oryza punctata) in Kenya
(African Journal of Agricultural Research, 2008)This shade house study examined the effect of competition on the growth performance of cultivated (Oryza sativa) and wild (Oryza punctata) rice species in Kenya. Growth was assessed for the two ... -
Traditional strategies used by pastoralists to cope with la nina induced drought in Kajiado, Kenya
(African Journal of Science and Technology, 2008)Pastoralists traditionally relied on herd mobility to cope with drought. In the pastoral areas of Kajiado, Kenya this strategy is now threatened by increased individual land ownership as compared to communal access. Drought ... -
Impact of the invader Ipomoea hildebrandtii on grass biomass, nitrogen mineralisation and determinants of its seedling establishment in Kajiado, Kenya
(African Journal of Range and Forage Science, 2008)The invasive coloniser Ipomoea hildebrandtii aggravates the problem of inadequate grass forage in Kajiado district, Kenya. To test its impact on grass biomass, nitrogen (N) mineralisation and seedling establishment, grazing ... -
Influence of cultivation, settlements and water sources on wildlife distribution and habitat selection in south-east Kajiado, Kenya
(Environmental Conservation, 2008)In Kenya, lands surrounding wildlife protected areas (PAs), referred to as dispersal areas, have undergone widespread land use changes, but these have been little studied. This study investigated impacts of different land ... -
Ecological, socio-economic and livelihood differentiation of Kenya’s Lembus forest proximate communities: The case of the Tugen and Lembus. Anthropologist
(2009)The Tugen and Lembus are indigenous communities found adjacent to the Lembus igenous forests. Other than these two communities, there are several others inhabiting this area the surrounding districts. The Lembus igenous ... -
Infectra(®)-kit: a device for restraining mice and confining tsetse flies during trypanosome infection transmission experiments
(Elsevier, 2013)Chemical (anaesthesia) and manual techniques are commonly used to restrain mice during vector-mediated parasite transmission experiments in the laboratory. Chemical restraint may interfere with natural fly vector-mouse ... -
Patterns of seed dispersal and establishment of the invader Prosopis juliflora in the upper floodplain of Tana River, Kenya
(African Journal of Range and Forage Science, 2011)Invasive species in Africa have important impacts on food security and biodiversity conservation. African floodplains in arid areas are critical wildlife habitats in addition to crop production and dry season livestock ... -
Plant Species Diversity and Composition of Two Wetlands in the Nairobi National Park, Kenya
(Asian Journal of Wetlands Ecology, 2012)Two wetlands (Hyena and Nalogomon) in the Nairobi National Park were investigated by comparing plant composition in and around their immediate vicinity. The most common aquatic plant species in the Hyena wetland was Cyperus ... -
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypano
(PLOS, 2013)There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the need for patient hospitalization, thus reducing healthcare costs ... -
Human impacts on two wetlands in Nairobi National Park
(Asian Journal of Wetlands Ecology, 2012)Environmental gradients in physico-chemical properties and distance to human settlements at two wetlands (around Hyena and Nalogomon dams) in the Nairobi National Park were studied. Ordination showed that over 84% of the ...