Sustainable Development Goal 6, target 2, aims to achieve universal access to sanitation by 2030, including the elimination of open defecation. This study investigated the impact of sanitation facility design, social factors, and technological suitability on promoting safe fecal management in Nyando Sub-County. The objectives were to examine how sanitation facility design, social factors, and technological suitability influence safe fecal management in the area. Frequent flooding in Nyando Sub-County often leads to the collapse of pit latrines, exacerbating open defecation and reversing the gains sanitation access. The study employed a convergent methods approach, incorporating both quantitative and qualitative techniques. A sample size of 177 households was selected using the Yamane (1967) formula from a total of 38,460 households. Data collection methods included structured questionnaires and focus group discussions. Quantitative data were analyzed using SPSS version 26, and relationships between variables were assessed using Pearson’s Product Moment correlation at a 5% significance level. MAXQDA software was used to analyze qualitative data by organizing it into themes. Results from regression analysis indicated significant influences of sanitation facility design (r =.507**, P ≤.019), social factors (r =.519**, P ≤.014), and technological suitability (r =.253**, P ≤.011) on promoting safe fecal management. The adjusted R-Square coefficient was 0.493, suggesting that the variables explained 49.3% of the factors influencing safe fecal management. The study found that 18.4% of respondents lacked toilets, and 55.2% had unimproved facilities. The study concluded that using appropriate construction materials and elevating toilets above flood levels, while ensuring accessibility and user-friendliness, could enhance their use during floods. Bridging socio-economic gaps and raising community awareness on improved sanitation are crucial to addressing sanitation inequalities. The study also recommended further research on other factors influencing the promotion of safe fecal management like Local Governance and Policy Support and Community Engagement and Participation. Additionally, more studies should be carried out to explore the suitable ecological sanitation alternatives for Nyando Sub-County to reduce the impact of flooding on sanitation facilities and public health