Browsing School of Health Sciences & School of Nursing by Author "Malhotra, Indu"
Now showing items 1-6 of 6
-
Birthweight in offspring of mothers with high prevalence of helminth and malaria infection in coastal Kenya
Fairley, Jessica K; Bisanzio, Donal; King, Charles H; Kitron, Uriel; Mungai, Peter; Muchiri, Eric; King, Christopher L; Malhotra, Indu (The American Society of Tropical Medicine and Hygiene, 2013)Results of studies on the associations of maternal helminth infection and malaria-helminth co-infection on birth outcomes have been mixed. A group of 696 pregnant women from the Kwale district in Kenya were recruited and ... -
Cord blood antiparasite interleukin 10 as a risk marker for compromised vaccine immunogenicity in early childhood
Malhotra, Indu; LaBeaud, A Desiree {et al} (The Journal of Infectious Diseases, 2018-01)Antenatal exposure to parasites can affect infants’ subsequent responses to vaccination. The present study investigated how maternal prenatal infections and newborns’ antiparasite cytokine profiles relate to immunoglobulin ... -
Development of a specimen-sparing multichannel bead assay to detect antiparasite IgG4 for the diagnosis of Schistosoma and Wuchereria infections on the coast of Kenya
DuVall, Adam S; Fairley, Jessica K; Sutherland, Laura; Bustinduy, Amaya L; Mungai, Peter L; Muchiri, Eric M; Malhotra, Indu; Kitron, Uriel; King, Charles H (The American Society of Tropical Medicine and Hygiene, 2014)To better delineate the impact of parasitic coinfection in coastal Kenya, we developed a novel specimen-sparing bead assay using multiplex flow immunoassay (MFI) technology to simultaneously measure serum or plasma ... -
Effect of antenatal parasitic infections on anti-vaccine IgG levels in children: a prospective birth cohort study in Kenya
Malhotra, Indu; McKibben, Maxim; Mungai, Peter {et al} (Public Library of Science, 2015)Parasitic infections are prevalent among pregnant women in sub-Saharan Africa. We investigated whether prenatal exposure to malaria and/or helminths affects the pattern of infant immune responses to standard vaccinations ... -
In utero activation of fetal memory T cells alters host regulatory gene expression and affects HIV susceptibility
Steiner, Kevin L; Malhotra, Indu; Mungai, Peter L; Muchiri, Eric M; Dent, Arlene E; King, Christopher L (Academic Press, 2012)In utero priming to malaria antigens renders cord blood mononuclear cells (CBMC) more susceptible to productive HIV infection in vitro in the absence of exogenous stimulation. This provides a unique model to better understand ... -
In utero activation of fetal memory T cells alters host regulatory gene expression and affects HIV susceptibility
Steiner, Kevin L; Malhotra, Indu; Mungai, Peter L; Muchiri, Eric M; Dent, Arlene E; King, Christopher L (Academic Press, 2012)The HIV-1 CCR5 co-receptor is a member of the chemokine receptor family of G-protein coupled receptors;for which a number of small molecule antagonists, such as vicriviroc (VCV), have been developed to inhibit HIV-1 R5-tropic ...