• Login
    View Item 
    •   Repository Home
    • Staff Publications
    • School of Agriculture & Food Science
    • View Item
    •   Repository Home
    • Staff Publications
    • School of Agriculture & Food Science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense

    Thumbnail
    View/Open
    Main Article (804.9Kb)
    Date
    1997
    Author
    Nyariki, James Nyabuga
    Thuita, John Kibuthu
    Nyambati, Grace Kemunto
    Isaac, Alfred Orina
    Metadata
    Show full item record
    Abstract
    Objective: To establish the modulatory effects of coenzyme Q10 on experimental trypanosome infections in mice and evaluate the risk of occurrence and severity of melarsoprol-induced post treatment reactive encephalopathy (PTRE). Methods: Female Swiss white mice were orally administered with 200 mg/kg of coenzyme Q10 after which they were intraperitoneally inoculated with Trypanasoma brucei rhodesiense (T. b. rhodesiense). The resultant infection was allowed to develop and simulate all phases of human African trypanosomiasis and PTRE. Parasitaemia development, packed cell volume, haematological and pathological changes were determined. Results: A histological study in the brain tissue of T. b. rhodesiense infected mice demonstrated neuroinflammatory pathology which was highly amplified in the PTRE-induced groups. A prominent reduction in the severity of the neuroinflammatory response was detected when coenzyme-Q10 was administered. Furthermore, the mean tissue weight of spleen to body ratio in coenzyme Q10 supplemented group was significantly (P<0.05) different compared to unsupplemented groups, and clearly indicated that coenzyme Q10 prevented full blown splenomegaly pathogenesis by T. b. rhodesiense. A significant (P<0.05) increase in hemoglobin levels and red blood cells was observed in coenzyme Q10 mice compared to those infected and un-supplemented with coenzyme Q10. Conclusions: The capacity of coenzyme Q10 to alter the pathogenesis of T. b. rhodesiense infection in mice and following treatment with melarsoprol, may find application by rendering humans and animals less susceptible to deleterious effects of trypanosome infection such as splenomegaly and melarsoprol-induced PTRE and neurotoxicity.
    URI
    http://repository.must.ac.ke/handle/123456789/443
    Collections
    • School of Agriculture & Food Science [251]

    MUST Repository copyright © 2002-2016  MUST Repository
    Contact Us | Send Feedback
    Theme by 
    MUST Repository
     

     

    Browse

    All of the RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    MUST Repository copyright © 2002-2016  MUST Repository
    Contact Us | Send Feedback
    Theme by 
    MUST Repository