Diamidines for human African trypanosomiasis
| dc.contributor.author | Paine, Mary F | |
| dc.contributor.author | Wang, Michael Zhuo | |
| dc.contributor.author | Generaux, Claudia N | |
| dc.contributor.author | Boykin, David W | |
| dc.contributor.author | Wilson, W David | |
| dc.contributor.author | Koning, Harry P De | |
| dc.contributor.author | Olson, Carol A | |
| dc.contributor.author | Pohlig, Gabriele | |
| dc.contributor.author | Burri, Christian | |
| dc.contributor.author | Brun, Reto | |
| dc.contributor.author | Murilla, Grace A | |
| dc.contributor.author | Thuita, John K | |
| dc.contributor.author | Barrett, Michael P | |
| dc.contributor.author | Tidwell, Richard R | |
| dc.date.accessioned | 2021-12-08T07:07:09Z | |
| dc.date.available | 2021-12-08T07:07:09Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Paine, M. F., Wang, M. Z., Generaux, C. N., Boykin, D. W., Wilson, W. D., De Koning, H. P., Olson, C. A., Pohlig, G., Burri, C., Brun, R., Murilla, G. A., Thuita, J. K., Barrett, M. P., & Tidwell, R. R. (2010). Diamidines for human African trypanosomiasis. Current opinion in investigational drugs (London, England : 2000), 11(8), 876–883. | en_US |
| dc.identifier.uri | http://repository.must.ac.ke/handle/123456789/496 | |
| dc.description.abstract | Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT); however, the drug must be administered parenterally and is active against first-stage HAT only, prior to the parasites causing neurological deterioration through invasion of the CNS. A major research effort to design novel diamidines has led to the development of orally active prodrugs and, remarkably, a new generation of compounds that can penetrate the CNS. In this review, progress in the development of diamidines for the treatment of HAT is discussed. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Thomson Reuters | en_US |
| dc.subject | Blood-brain barrier | en_US |
| dc.subject | Clinical Trail | en_US |
| dc.subject | Diamidine | en_US |
| dc.subject | Drug metabolism | en_US |
| dc.subject | Drug transport | en_US |
| dc.subject | Furamidine | en_US |
| dc.subject | Human African trypanosomiasis | en_US |
| dc.subject | Pentamidine | en_US |
| dc.subject | Sleeping sickness | en_US |
| dc.title | Diamidines for human African trypanosomiasis | en_US |
| dc.type | Article | en_US |