Assessment of Zinc Intake, Status and Influencing Factors in Kenya
Date
2015Author
Ngigi, Peter B
Laing, Gijs Du
Lachat, Carl
Masinde, Peter W
Metadata
Show full item recordAbstract
Zinc    (Zn)    is    vital    for    many    biological    functions    and    plays    a    crucial    role    in    more    than    300    enzymes  in  the  human  body (Brown    &    Wuehler    2002).    The    risk    of    low    dietary    intake    of    absorbable    
Zn    and    consequent    deficiency    is    a    widespread    problem    in    Sub-‐Saharan    Africa    (SSA).    In    Kenya    Zn    deficiency    occurs    in    about    half    of    the    children,    mothers    and    men;    diarrhoea,    hookworm    and    
anaemia  are    the    main    risk    factors    for    hypozincaemia    among    children    (Save    the    Children    2012);    anaemia    and    respiratory    tract    illnesses    are    each    associated    with    nearly    two-‐fold    increase    in    risk    of    hypozincaemia    among    mothers    -‐pregnancy    further    exacerbated    the    risk    of    zinc    deficiency;    while    schistosoma    infections    and    Vitamin    A    deficiency    are    associated    with    two-‐fold    increase    in    the    risk    of    hypozincaemia    in    men    (Republic    of    Kenya    2011).    Because    of    the    likely    high    national prevalence    of    Zn    deficiency    and the    serious    range    of    complications,    sustainable    interventions    are    needed    to    boost    zinc    intakes    (Ministry    of    Public    Health    and    Sanitation    2008).    As    diet    is    the    most    important    source    of    Zn,    collection    of    dietary    intake    data    is    of    primary    importance    for    the    
identification,    treatment,    and    management    of    Zn    deficiency    disorders.    Zn    interacts    with    other    elements    which    are    deficient    in    SSA    such    as    selenium    (Se)    and    therefore    analysis    of    Se    will    be    included    in    this    study    (Joy    et.    al. 2014,    Eybl    et.    al.1999).    Therefore,    we    are    currently    conducting    a    cross-‐sectional    descriptive    survey    aimed    at    assessing    the    Zn    intake    and    status    among    the    6-‐59    months    old    children    and    their    mothers    in    Kenya.    Dietary    intake    data    combined    with    the    Zn    content    of    local    foods    will    institute    the    actual    intake    for    selected    29    study    areas    in    the    agricultural    production    zones;    21    regions    in    the    central    Kenya    highlands    and    8    regions    along    the    Lake    Victoria    basin.    Food,    soil,    hair    and    nail    samples    will    be    taken    
from    the    selected    households.    The    association    between    soil    Zn    and    crop    Zn,    and    between    population    Zn    status    and    Zn    intake    will    help    to    determine    the    soil    characteristics    that    influence   soil-‐to-‐plant    Zn    transfer,    and    dietary    factors    that    influence    Zn    status    among    the    population.    Past    nutrition    interventions    such    as    supplementation    and    food    fortification    have    failed    to    reach    the    rural    
population.    Therefore,    it    is    intended    to    also    conduct    Zn,    and    Se    agronomic    biofortification    trials    in    a    next    phase,    as    a    possible    solution    to    the    ‘hidden    hunger’.Study    areas    were    identified    first    based    on    the    various    soil    types    used    for    agriculture    in.  Kenya.    Correlation    between    Zn    in    plant    and    soil    can    be    found    if    the    relationship    is    investigated    within various    soils    types;    the    mobility    and    plant-‐availability    of    Zn    in    soil    is    controlled    by    a    number    of    soil’s  chemical    and    biochemical    processes.    The    second    criteria    was    based    on    fish    consumption    habits   since  sea    foods    are    one    of    the    best    dietary    sources    of    Zn.    The    target    population    is 6-‐59    months    old    children    and    their    mothers    because    Zn    plays    an    important    role    in    facilitating    the    folding    of    proteins    into    the    biologically    active    molecules    used    in    gene    regulation.    It    is    therefore    critical    for    cell    replication    and    normal    growth.    Zn    deficiency    depresses    growth resulting    to    stunting    an    important    problem    in    young    children    in    SSA.    Child    growth    can    therefore    be    used    as    an    evaluation    criteria    for    the    impact    of    interventional    measures    beside    the    93 biochemical    markers.    Based    on    a    Zn
deficiency    proportion    of    50%    among    children    in    Kenya,    754    subjects    are    needed    for    the    study.    From    the    randomly    selected    households    in    each    study    area,    a    composite    100    g    soil    samples    will    be    collected    from    the    farm,    40g    of    each    food    produced    for    the    
farm,    1.5    to    2    g    of    hair    samples    and    10-‐50    mg    of    nail    samples    depending    on    availability.    All    the    samples    will    be    transported    to    Belgium    and    analysed    at    the    Laboratory    of    Analytical    Chemistry    and    Applied    Ecochemistry,    Ghent    University. Laboratory    results    and    dietary    intake    data    will    be    analysed    with    STATA    statistical    package.    Soil-‐plant    and    Zn    status-‐dietary    intake    regression    models    will    be    derived    to    determine    the    relation    between    Zn    concentrations    in    crops    and    soil    characteristics    and    the    relation    between    Zn    concentration    in    hair    and    nail    and    dietary    Zn    characteristics    (concentration    in    hair    and    nail,    dietary    intake),    respectively.    
Results. 
Samples    are    currently    still    being    collected    in    Kenya.    Dietary    intake    data    combined    with    the    
Zn    concentration    of    local    foods    plus    soil    Zn    concentration    will    reflect    the    Zn    exposure    at    the    
population    level.    Hair    and    nail    samples    will    be    used    to    assess    Zn    status    at    the    individual    level.    The    fact    that    soil    types    were    included    as    a    selection    criterion    for    the    sampling    sites    allows    us    to    study    correlations    between    Zn    concentrations    in    plant    and    soil    to    assess    the    mobility    and    plant-‐availability    of    Zn    in    the    soil,    which    is    controlled    by    a    number    of    chemical    and    biochemical    processes.    The    association    between    soil    Zn    and    crop    Zn    concentration    will    help    to    determine    the    soil    characteristics    that    influence    soil-‐to-‐plant    Zn    transfer,    while    the    association    between    population/individual    Zn    status    and    Zn    intake    will    help    to    determine    dietary    factors    that    influence    Zn    status    among    the    target    population.    Regression    models    will    be    used    to    determine    the    relationship    between    Zn    concentrations    in    crops    and    soil    characteristics,    and    the    relationship   between    Zn    concentration    in    hair/nail    and    dietary    Zn    characteristics, respectively.

