Researchers and post-graduate students most of the time have a challenge differentiating between research philosophies, research design and research methodologies. This paper therefore focuses conducting a systematic review to bring forth clarity on the differences between; research philosophy, research design, research methodologies and research paradigms in Information Technology research. The paper also highlight on the hallmarks of scientific research, fundamental of scientific research, elements of research design as well as data analysis techniques. The paper observes research philosophy, design and methodology and implications in Information Technology literature. This paper contributes to the exploration and identification of qualitative and quantitative methodologies, sampling style, sample size for different Information Technology researches. The authors used content analysis to review works done by other scholars to draw conclusions. The paper would greatly improve the quality of research work by the junior researchers, or post-graduate students who are still developing their research skills.